Manganese-Enhanced Magnetic Resonance Imaging: …
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese …
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese …
Synopsis: In this chapter the reader is introduced to the phenomenon of magnetic resonance, with its associated physical aspects (i.e., the magnetic moment, susceptibility, magnetization precession, etc.).The reader will then learn about principles of MRI pulse sequencing and signal generation, the gradient fields, and the methodologies implemented for …
Dynamic manganese-enhanced magnetic resonance imaging (MEMRI) detects neuronal activity based on the passage of Mn 2+ into active neurons. Because this mechanism is independent of any hemodynamic response, it is potentially ideal for pharmacological studies and was applied to investigate the acute CNS effects of cocaine in the rat.
This chapter will emphasize the methodological approaches towards the use of MEMRI in biological systems. The use of manganese ions (Mn(2+)) as an MRI contrast agent was introduced over 20 years ago in studies of Mn(2+) toxicity in anesthetized rats (1). Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered …
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T1 relaxation time of tissue water protons that become exposed to …
Conclusions: MEMRI has the potential to noninvasively distinguish different metastatic potential CRCs. However, the MnSOD expression is not correlated to malignant potential in CRC cells. Keywords: Colorectal cancer, Contrast-enhanced magnetic resonance imaging (MRI), Manganese, Metastatic potential, Manganese superoxide dismutase Keypoints
Rationale Manganese (Mn2+)-enhanced magnetic resonance imaging (MEMRI) is an emerging in vivo MR approach for pharmacological research. One new application of MEMRI in this area is to characterize functional changes of a specific neural circuit that is essential to the central effects of a drug challenge. Objectives To develop and validate such use of MEMRI in …
In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed. 17 595–601. 10.1002/nbm.942 [Google Scholar] Pautler R. G., Silva A. C., Koretsky A. P. (1998). In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn. Reson.
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn 2+.Mn 2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn 2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to …
The use of manganese ions (Mn 2+) as an MRI contrast agent was introduced over 20 years ago in studies of Mn 2+ toxicity in anesthetized rats ().Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements as well as neuronal tract tracing ().Currently, MEMRI has three primary …
In contrast, manganese-enhanced magnetic resonance imaging (commonly termed MEMRI) can provide a noninvasive in vivo assessment of axonal transport at the macroscopic scale. MEMRI is based on two important physico-chemical properties of manganese (Mn 2+).
Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Methods Mol Biol. 2022:2431:111-142. doi: 10.1007/978-1-0716-1990-2_6. ... LLC, part of Springer Nature. Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't MeSH terms Animals
Visual demonstration of precession. Redrawn from Figure 2 of Jackson et al. ().The nucleus's axis of rotation (dotted line) does not exactly align with the magnetic field B 0 (solid line). As the nucleus rotates around the B 0, it also spins on its own axis.The frequency with which the nucleus rotates around B 0, termed the precession, is inherent to each species and scales linearly with …
Manganese-enhanced magnetic resonance imaging (MEMRI) Alan P. Koretsky* and Afonso C. Silva Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Received 3 October 2004; Revised 6 October 2004; Accepted 6 October 2004
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. ...
Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations Afonso C. Silva,1* Jung Hee Lee,1 Ichio Aoki2 and Alan P. Koretsky1 1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
There is growing interest in the use of manganese-enhanced MRI (MEMRI) to detect neuronal activity and architecture in animal models. The MEMRI neuronal activity studies have been generally performed either by stereotactic brain injection or by systemic administration of Mn2+ in conjunction with the disruption of the blood–brain barrier (BBB).
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connecti …
1-weighted magnetic resonance imaging (MRI), specific to tissues in which the ion has accumulated. Manganese-enhanced MRI (MEMRI) uses a combination of ... Key Words: Manganese ion; Mn2+; magnetic resonance imaging; MRI; manganese-en-hanced MRI; MEMRI; brain; mouse; rat; rodent; olfactory; neuronal tracts; tract tracing; car-
The use of manganese ions (Mn(2+)) as an MRI contrast agent was introduced over 20 years ago in studies of Mn(2+) toxicity in anesthetized rats (1). Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements (2) …
Magnetic resonance imaging (MRI)Magnetic resonance imaging (MRI) provides a non-destructive approach to peer into opaque tissues like the brain. The paramagnetic ion, manganese (MnII), gives a hyperintense signal in T 1 weighted MRIMagnetic resonance imaging (MRI) that can serve as a marker for axonal transportAxonal transport (at).
Saleem K. S., Pauls J. M., Augath M., et al. (2002) Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 34, 685–700. Van der Linden A., Verhoye M., Van Meir V., et al. (2002) In vivo manganeseenhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system.
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T 1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: …
To this end, we now report that manganese (Mn 2+)-enhanced magnetic resonance imaging (MEMRI) can reflect brain region-specific HIV-1-induced neuropathology in …
magnetic resonance imaging (MEMRI) is a powerful tool widely applied to verify the distribution of man-ganese in the mouse brain in vivo. In 1989, MEMRI was first described and proved to be a useful tool to study the neuronal activity or toxic manganese sno i ( Mn 2+) in the rodent brain, which based on the
nese injected in MEMRI studies can disrupt the homeostasis of other transition metals in mice. Keywords Manganese enhanced magnetic resonance imaging (MEMRI) Mouse brain Iron Copper X-ray fluorescence (XRF) Neutron activation analysis (NAA) Introduction Manganese-enhanced magnetic resonance imaging (MEMRI) is widely used in animal imaging, with
In Vivo Tracking of Transplanted Mononuclear Cells Using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Kenichi Odaka, 1 Ichio Aoki, 1, * Junji Moriya, 2 Kaoru Tateno, 2 Hiroyuki Tadokoro, 3 Jeff Kershaw, 1 Tohru Minamino, 2 Toshiaki Irie, 1 Toshimitsu Fukumura, 1 Issei Komuro, 2 and Tsuneo Saga 1
Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice Aditya N. Bade1 & Santhi Gorantla1 & Prasanta K. Dash1 & Edward Makarov1 & Balasrinivasa R. Sajja2 & Larisa Y. Poluektova1 & Jiangtao Luo3 & Howard E. Gendelman1 & Michael D. Boska1,2 & Yutong Liu1,2 Received: 18 February …
Springer Protocols (2014) Using Manganese-Enhanced MRI to Assess Optic Nerve Regeneration Authors: Ioanna Sandvig 1 ... Axonal tracing of the normal and regenerating visual pathway of mouse, rat, frog, and fish using manganese-enhanced magnetic resonance imaging (MEMRI). J Magn Reson Imaging 34: 670–675
Manganese-enhanced magnetic resonance imaging is a technique that employs the divalent ion of the paramagnetic metal manganese (Mn2+) as an effective contrast agent to visualize, in vivo, the mammalian brain. As total achievable contrast is directly proportional to the net amount of Mn2+ accumulated in the brain, there is a great interest in optimizing …
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